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The most widely-used pairwise sequence comparison algorithms for homology detection, such as BLAST and PSI-BLAST, often fail to detect less conserved
BLAST (Basic Local Alignment Search Tool) BLAST (Stand-alone) E-Utilities Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(10):1498-1502. [
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Pseudouridylation (Psi) of U2 snRNA in S. cerevisiae is catalyzed by anA BLAST search revealed Pus7 homologs in various organisms.doi:10.1093/
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Efficient recognition of protein fold at low sequence identity by conservative application of Psi-BLAST: Application doi:10.1002/jmr.719Journal of Molecular
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The PSI-BLAST algorithm enhances the sen- sitivity of BLAST searches by using the information contained in a multiple alignment of sequences similar to
